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We study paralogous factors with similar motifs, but different genomic targets and regulatory roles

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We use gcPBM assays to identify differences in DNA-binding specificity between paralogous transcription factors

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We use weighted regression to model differential specificity of paralogous TFs

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http://imads.genome.duke.edu

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We find that differences in intrinsic specificity partly explain differential in vivo binding

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We develop quantitative models of TF-DNA binding based on sequence and shape features

Welcome to the Gordan Lab

We develop quantitative computational and experimental approaches to identify and characterize transcriptional regulatory regions in the human genome. We combine machine learning techniques and high-throughput assays. Focusing on transcription factors (TFs) that control cell proliferation and differentiation, our goals are to understand: (1) how these regulatory proteins interact with each other to select their unique targets across the genome, and (2) how this regulation is disrupted in diseased cells due to non-coding mutations and TF overexpression.

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